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Home - Products - Cell Cycle/DNA Damage - ATM/ATR - Ro 90-7501

Ro 90-7501

CAS No. 293762-45-5

Ro 90-7501( —— )

Catalog No. M33482 CAS No. 293762-45-5

Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 90-7501
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.
  • Description
    Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation Dosage:5 μg/g Administration:Intraperitoneal injection; daily; for 21 days Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ATM/ATR
  • Recptor
    ATM/ATR | Apoptosis | Phosphatase | Gamma-secretase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    293762-45-5
  • Formula Weight
    340.38
  • Molecular Formula
    C20H16N6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (122.42 mM; Ultrasonic )
  • SMILES
    NC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810.?
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